Selected Publications
1. Sundaresan NR, Vasudevan P, Zhong L, Kim G, Samant S, Parekh V. Pillai V, Ravindra P, Gupta M, Jeevanandam V, Cunningham J, Deng C, Lombard D, Mostoslavsky R and Gupta MP. The sirtuin SIRT6 blocks IGF/Akt signaling and development of cardiac hypertrophy by targeting c-Jun. Nature Medicine 18: 1643-1650, 2012. This paper was discussed in News and Views of Nat. Med 18: 1617-1619, 2012.
2. Sundaresan NR Pillai V, Samant S, Wolfgeher D, Vasudevan P Vishwas Parekh V, Cunningham JM, Gupta M and Gupta MP. The deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophy. Science Signaling 4 (182): ra46-58, 2011.
3. Knezevic I, Patel A, Sundaresan NR, Gupta MP, Solaro RJ, Nagalingam RS, Gupta M. A novel cardiomyocyte-enriched microRNA, miR-378, targets insulin-like growth factor 1 receptor: implications in postnatal cardiac remodeling and cell survival. Journal Biological Chemistry 287: 12913-12926, 2012.
4. Pillai V, Sundaresan NR, Samant S, Wolfgeher D, Trivedi CM and Gupta MP. Acetylation of a conserved lysine residue in the ATP-binding pocket of p38 augments its kinase activity during hypertrophy of cardiomyocytes. Molecular Cellular Biology 31: 2349-2363, 2011. PMID 21444723 (The paper is selected as hottest article of significant interest by Editors, MCB 31:2137, 2011).
5. Samant, SA, Sundaresan NR, Courson DS, Pillai, V, Rock, RS and Gupta MP. HDAC3-dependent reversible lysine acetylation of cardiac myosin heavy chain isoforms modulates their enzymatic and motor activity. Journal Biological Chemistry 286: 5567-77, 2011.
6. Pillai V, Sundaresan NR, Kim G, Gupta M, Rajamohan SB, Pillai JB, Samant S, Ravindra, PV, Isbatan A and Gupta MP. Exogenous NAD blocks cardiac hypertrophic response via activation of the SIRT3-LKB1-AMPK pathway. Journal Biological Chemistry 285: 3133-3144, 2010.
7. Sundaresan NR, Gupta M, Kim G, Rajamohan SB, Isbatan, A and Gupta MP. SIRT3 blocks the cardiac hypertrophic response by augmenting the Foxo3a-dependent anti-oxidant defense mechanism in mice. Journal Clinical Investigation 119: 2758-2771, 2009.
8. Rajamohan SB, Pillai VB, Gupta M, Sundaresan NR, Konstatin B, Samant S, Hottiger M and Gupta MP. SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of Poly (ADP) ribose polymerase 1. Molecular Cellular Biology 29: 4116-4129, 2009.
9. Sundaresan NR, Samant SA, Pillai VB, Rajamohan SB and Gupta MP. SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell-death by deacetylation of Ku70. Molecular Cellular Biology 28:6384-6401, 2008.
10. Gupta MP, Samant S, Smith SH and Shroff SJ. HDAC4 and PCAF bind to cardiac sarcomeres and play a role in regulating the myofilament contractile activity. Journal Biological Chemistry 283: 10135-10146, 2008.
11. Pillai, JB, Isbatan A, Imai SI and Gupta MP. Poly (ADP-ribose) polymerase-1 dependent cardiac myocyte cell-death during heart failure is mediated by NAD+ depletion and reduced activity of the SIRT1 deacetylase. Journal Biological Chemistry 280:43121-43130, 2005.
12. Gupta, M., Sueblinvong, V., Raman, J., Jeevanandam, and Gupta, M.P. Single-strand DNA-binding proteins, PURa and PURb, bind to a negative regulatory element of the a-myosin heavy chain gene and control the transcriptional and translational regulation of gene expression: Implications in the repression of a-MHC during heart failure. Journal Biological Chemistry 278: 44935-44948, 2003.
13. Davis, F.J., Gupta, M., Camoretti-Mercado, B, Schwartz, R.J. and Gupta, M.P. Calcium/calmodulin-dependent protein kinase activates serum response factor transcription activity by its dissociation from histone deacetylase, HDAC4: implications in cardiac muscle gene regulation during hypertrophy. Journal Biological Chemistry 278: 20047-20058, 2003.
14. Gupta, M., Kogut, P. Francesca J. D, Belaguli, N.S. Schwartz, R.J and Gupta, M.P. Physical interaction between the MADS box of serum response factor and the TEA/ATTS DNA-binding domain of transcription enhancer factor-1. Journal Biological Chemistry 276:10413-10422, 2001.
15. Gupta, M., Zak R., Liebermann, T.W., and Gupta, M.P. Tissue-restricted expression of the cardiac α-myosin heavy chain gene is controlled by a down-stream repressor element containing a palindrome of two Ets-binding sites. Molecular Cellular Biology 18: 7243-7258, 1998.
2. Sundaresan NR Pillai V, Samant S, Wolfgeher D, Vasudevan P Vishwas Parekh V, Cunningham JM, Gupta M and Gupta MP. The deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophy. Science Signaling 4 (182): ra46-58, 2011.
3. Knezevic I, Patel A, Sundaresan NR, Gupta MP, Solaro RJ, Nagalingam RS, Gupta M. A novel cardiomyocyte-enriched microRNA, miR-378, targets insulin-like growth factor 1 receptor: implications in postnatal cardiac remodeling and cell survival. Journal Biological Chemistry 287: 12913-12926, 2012.
4. Pillai V, Sundaresan NR, Samant S, Wolfgeher D, Trivedi CM and Gupta MP. Acetylation of a conserved lysine residue in the ATP-binding pocket of p38 augments its kinase activity during hypertrophy of cardiomyocytes. Molecular Cellular Biology 31: 2349-2363, 2011. PMID 21444723 (The paper is selected as hottest article of significant interest by Editors, MCB 31:2137, 2011).
5. Samant, SA, Sundaresan NR, Courson DS, Pillai, V, Rock, RS and Gupta MP. HDAC3-dependent reversible lysine acetylation of cardiac myosin heavy chain isoforms modulates their enzymatic and motor activity. Journal Biological Chemistry 286: 5567-77, 2011.
6. Pillai V, Sundaresan NR, Kim G, Gupta M, Rajamohan SB, Pillai JB, Samant S, Ravindra, PV, Isbatan A and Gupta MP. Exogenous NAD blocks cardiac hypertrophic response via activation of the SIRT3-LKB1-AMPK pathway. Journal Biological Chemistry 285: 3133-3144, 2010.
7. Sundaresan NR, Gupta M, Kim G, Rajamohan SB, Isbatan, A and Gupta MP. SIRT3 blocks the cardiac hypertrophic response by augmenting the Foxo3a-dependent anti-oxidant defense mechanism in mice. Journal Clinical Investigation 119: 2758-2771, 2009.
8. Rajamohan SB, Pillai VB, Gupta M, Sundaresan NR, Konstatin B, Samant S, Hottiger M and Gupta MP. SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of Poly (ADP) ribose polymerase 1. Molecular Cellular Biology 29: 4116-4129, 2009.
9. Sundaresan NR, Samant SA, Pillai VB, Rajamohan SB and Gupta MP. SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell-death by deacetylation of Ku70. Molecular Cellular Biology 28:6384-6401, 2008.
10. Gupta MP, Samant S, Smith SH and Shroff SJ. HDAC4 and PCAF bind to cardiac sarcomeres and play a role in regulating the myofilament contractile activity. Journal Biological Chemistry 283: 10135-10146, 2008.
11. Pillai, JB, Isbatan A, Imai SI and Gupta MP. Poly (ADP-ribose) polymerase-1 dependent cardiac myocyte cell-death during heart failure is mediated by NAD+ depletion and reduced activity of the SIRT1 deacetylase. Journal Biological Chemistry 280:43121-43130, 2005.
12. Gupta, M., Sueblinvong, V., Raman, J., Jeevanandam, and Gupta, M.P. Single-strand DNA-binding proteins, PURa and PURb, bind to a negative regulatory element of the a-myosin heavy chain gene and control the transcriptional and translational regulation of gene expression: Implications in the repression of a-MHC during heart failure. Journal Biological Chemistry 278: 44935-44948, 2003.
13. Davis, F.J., Gupta, M., Camoretti-Mercado, B, Schwartz, R.J. and Gupta, M.P. Calcium/calmodulin-dependent protein kinase activates serum response factor transcription activity by its dissociation from histone deacetylase, HDAC4: implications in cardiac muscle gene regulation during hypertrophy. Journal Biological Chemistry 278: 20047-20058, 2003.
14. Gupta, M., Kogut, P. Francesca J. D, Belaguli, N.S. Schwartz, R.J and Gupta, M.P. Physical interaction between the MADS box of serum response factor and the TEA/ATTS DNA-binding domain of transcription enhancer factor-1. Journal Biological Chemistry 276:10413-10422, 2001.
15. Gupta, M., Zak R., Liebermann, T.W., and Gupta, M.P. Tissue-restricted expression of the cardiac α-myosin heavy chain gene is controlled by a down-stream repressor element containing a palindrome of two Ets-binding sites. Molecular Cellular Biology 18: 7243-7258, 1998.