Laboratory of Mahesh P. Gupta
MS, All-India Institute of Medical Sciences, New Delhi
PhD, All-India Institute of Medical sciences, New Delhi (a premier institute of India)
Post-doc, University of Chicago, Mentor, Dr. Radovan Zak
Professor
Director Basic Cardiothoracic Surgery Research Program, Department of Surgery
Member, Committee on Cellular and Molecular Physiology
Member, Committee on Molecular Medicine
University of Chicago
5841 S. Maryland Avenue
Chicago, IL 60637
Contact: [email protected]
PhD, All-India Institute of Medical sciences, New Delhi (a premier institute of India)
Post-doc, University of Chicago, Mentor, Dr. Radovan Zak
Professor
Director Basic Cardiothoracic Surgery Research Program, Department of Surgery
Member, Committee on Cellular and Molecular Physiology
Member, Committee on Molecular Medicine
University of Chicago
5841 S. Maryland Avenue
Chicago, IL 60637
Contact: [email protected]
Cover page figures of journals with our publications:
Molecular basis of cardiac remodeling and heart failure
The main focus of our research is to understand the molecular mechanism of cardiac dysfunction and development of heart failure (HF). In the past decades, although there have been important advances in our understanding of the mechanisms and treatments of HF, the morbidity and mortality attributed to HF continues to rise. Several functional abnormalities involving calcium homeostasis, contractile protein function, energetic and cytoskeleton rearrangement have been identified in the hypertrophied and failing myocardium. But the basic molecular mechanism associated with these abnormalities is not yet fully understood. Our laboratory is interested in understanding the role played by HDACs and sirtuins in the evolution and progression of HF. We have currently four main projects running in our laboratories to understand the etiology of this disease.
(1) Role of PARP-SIRT1 axis of signaling in the development of heart failure.
(2) Activating Sirtuins to prevent adverse cardiac remodeling post MI.
(3) Blocking cardiotoxicity of anti-cancer drugs to the heart.
(4) Role of sirtuins in the aging associated heart and skeletal muscle diseases.
(1) Role of PARP-SIRT1 axis of signaling in the development of heart failure.
(2) Activating Sirtuins to prevent adverse cardiac remodeling post MI.
(3) Blocking cardiotoxicity of anti-cancer drugs to the heart.
(4) Role of sirtuins in the aging associated heart and skeletal muscle diseases.